Drugs showing zero order kinetics of elimination_____________?
(A) Are more common than first order kinetics
(B) Decrease in concentration exponentially with time
(C) Have a half – life independent of dose
(D) Show a plot of drug concentration versus time that is linear
Zero order kinetics is seen with_______________?
(A) Phenytoin
(B) Phenabarbtion
(C) Erythromycin
(D) Digoxin
Idiosyncracy is known as to have_____________?
(A) Genetic component
(B) Psychological component
(C) Psysiological component
(D) Nutritional component
Neuro adaptation to drug is same as______________?
(A) Physical dependence
(B) Psychological dependence
(C) Addiction
(D) Habituation
Which drugs had high first pass effect_____________?
(A) Amiodarone
(B) Phenytoin
(C) Verapamil
(D) Disorpyamide
Combination of ampicillin and gentamicin is an example of_____________?
(A) Indifference
(B) Synergy
(C) Antagonism
(D) Bacterial symbiosis
All of the following statements regarding biovailability of a drug are true except______________?
(A) It is the proportion (fraction) of unchanged drug that reaches the systemic circulation
(B) Biovailability of an orally administered drug can be calculated by comparing the area under cure (o-a) after oral and intravenous (IV) administration
(C) Low oral biovailability always and necessarily mean poor absorption
(D) Biovailability can be determined from plasma concentration or urinary excretion data
Drug efficacy refers to_________________?
(A) Range of disease in which the drug beneficial
(B) Maximal intensity of response that can be produced by the drug
(C) The therapeutic does range of the drug
(D) The therapeutic index of the drug
Intramuscular route is precluded during the medication of________________?
(A) Anti-hypertensives
(B) Anti-diabetics
(C) Anticoagulants
(D) Anti-fibrinolytics
Drug not requiring dose adjustment in renal disease is___________?
(A) Aminoglycoside
(B) Vancomycin
(C) Calcium channel blocker
(D) Metronidazole